Abstract: Dynamics of cell spreading in the whole cell population is formed by dynamics of spreading of individual cells. In attempt to reveal regularities of spreading for the whole cell population we have measured Area, Perimeter and spreading-coefficient of the cells. Within 3 h upon plating of the cells on various substrates, cell spreading is a two-phase process, with retardation of spreading between 60 and 90 min after plating. The external factors (in particular, a type of substrate) do not influence on the character of cell spreading but affect only on the spreading rate. We suggest that these phenomena are based on such fundamental properties action as assembly and disassembly of filaments indicating a sharp transition from a globular to polymeric action state.