Abstract: Eleven aqueous plant extracts from 8 traditionally used Nigerian medicinal plants Adasonia digitata L. (Bombacaceae), Bryophyllum pinnatum Lam. (Crassulaceae), Cajanus cajan (L.) Mill sp. (Fabaceae), Carica papaya L. (Caricaceae), Cissus populnea Guill and Perr (Vitaceae) Parquetina nigrescens (Afzel.) Bullock (Periplocaceae), (Terminalia catappa L.) (Combretaceae) and Zanthoxylum xanthoxyloides (Lam.) Waterman (Rutaceae) were evaluated for their cationic constituents as a measure of their efficacy in sickle cell anemia disorder. Extracts were subjected to dry ash digestion and the resultant supernatants were used for macro- and micronutrients determination using the emission flame photometer and the absorption spectrophotometer. K+, Na+, Fe2+ and Zn2+ were relatively higher than Ca2+ and Mg2+ in the tested extracts. The presence of these cations, K+, Na+, Ca2+ and Mg2+ implicated in the process of sickling and involved in electrolytes movement in the physiological system of the body may be an important parameter in sickle cell anemia management.