Abstract: Eight bread wheat (Triticum aestivum L.) cultivars were crossed in a diallel fashion and evaluated for heterosis in F1 generation for grain yield and other economic traits under leaf rust conditions. Highly significant differences were found among genotypes for all the traits studied. Significant positive heterosis and heterobeltiosis was observed for grain yield per plant in almost all crosses. Estimates for positive significant heterosis over mid and better parents for plant height were 68 and 32% of total crosses where as 44 and 35 crosses gave significant positive increased tillers per plant over their mid and better parents, respectively. Positive and significant heterotic effects were measured as 11.61, 61.90, 30.67, 2.3, 51.89, 126.64, 111.71 and 45.91% from crosses SA42 x Nacozari, MH 97 x Crow, Parula x Chenab70, Crow x Nacozari, Crow x Chenab70, SA42 x Nacozari, MH97 x SA42 and Nacozari x Chenab for plant height, tillers per plant, grains per spike, spikelets per spike, grain weight, grain yield, biological yield per plant and harvest index, respectively.