Abstract: fine structure of adrenal gland in the toad, (Bufo tibamicus) and the desert reptile, (Uromastyx philbyi). The adrenal glands of both animals are composed of adrenocortical and chromaffin tissues. In B. tibamicus, The adrenocortical tissue is comprised of two main types of cells, the steroid cells with abundance of lipid inclusions and eosinophilic cells with eosinophilic granular cytoplasm. The chromaffin tissue is intermingled with adrenocortical tissue. They are formed of adrenaline and nor-adrenaline secreting cells with different electron density and variable sizes. The adrenocortical cells of U. phiblyi constituent the main bulk of the inner gland and they are typical steroid-secreting cells. They also characterized by their rich amount of lipid droplets. Cords or islets of inner chromaffin cells are scattered throughout the adrenocortical cells. The outer portion of the gland is composed of chromaffin cells surrounded by the capsule. Adrenaline and nor-adrenaline secreting cells were distinguished by means of different electron density of their chromaffin granules either in the outer or inner portion of the gland.