Abstract: The effect of Olitref and Agil weedicides alone and in combination was studied in cotton. Combine application of Olitref and Agil at pre and post emergence stages respectively gave the best weed control and the maximum seedcotton yield (2415 kg ha-1). Olitref weedicide was found better than Agil and the yield was 2093 kg ha-1 and 1863 kg ha-1 respectively. The seedling density and final plant height were not effected by the application of weedicides. However, the plots treated with Olitref and Agil gave the maximum plant height of (167.75 cm). The number of mature bolls per plant was also maximum in plots where these weedicides were applied.