Abstract: Background and Objective: Anaemia is common in the elderly and its prevalence increases with age. This work aimed to estimate the haemoglobin concentration, packed cell volume and some iron related parameters (SI, TIBC and TS) of people in Calabar South Local Government Area (LGA) of Cross River state, Nigeria. Materials and Methods: Haemoglobin estimation and packed cell volume were done using the cyanmethaemoglobin method and microhaematocrit method, respectively, while the iron related parameters were measured using the colorimetric method. Forty control subjects comprising of 21 males (52.5%) and 19 females (47.5%) with 47 elderly people made up of 18 males (38.3%) and 29 females (61.7%) with age range of 65-78 years, mean age of 68±4.5 were used for this study. Results: Packed cell volume (PCV), haemoglobin concentration (Hb), Mean cell haemoglobin concentration (MCHC), serum iron (SI) and transferrin saturation (TS) showed a significant decrease in elderly people (0.35±0.33 L L–1, 111±11.1 g L–1, 31.9±0.63%, 66±15.4 μg dL–1 and 24±8.07%) and slight increase in total iron binding capacity (TIBC) (296±79.9 μg dL–1) when compared to the control subjects. There was a strong positive significance correlation between Hb and PCV (r = 0.982, p<0.05), while mild significant positive correlation was seen between TS and Hb (r = 0.329, p<0.05) of the elderly people which are pointers to iron deficiency. Conclusion: This study revealed that haemoglobin, PCV and iron related parameters are reduced in elderly people in Calabar South LGA, Calabar. Caregivers should be made to understand the basic requirement of the elderly, which is adequate diet, mineral and iron supplement to avoid anaemia in them.