Abstract: Background and Objective: Environmental pollution with cadmium is one of the most deleterious agents to the biological life. Industries such as cement plants, batteries and smoke offered additional hazards to the environment surrounding man and animals. The present study aimed to assess the protective effects of high dose of lipoic acid on cadmium-induced toxicity in rats. Materials and Methods: The experiment was carried out on 30 male albino rats, these rats were divided randomly into 3 groups (n = 10 rats): Control group (0.5 mL phosphate-buffered physiological saline orally), Cd group (5 mg kg–1 b.wt., cadmium chloride (CdCl2) orally). LA+Cd group (5 mg kg–1 b.wt.,/day CdCl2+100 mg kg–1/day Lipoic acid orally). All treatments were administered daily for 30 days. Results: The study revealed that the administration of cadmium chloride induced a significant increase in serum alanine transaminase (ALT), aspartate transaminase (AST), creatinine and urea. In addition, cadmium significantly decreased the serum total protein, albumin concentrations and acetyl cholinesterase activity. It also induced a significant increase in catalase (CAT), superoxide dismutase (SOD), Malondialdehyde (MDA) and DNA fragmentation (%) in liver and kidney tissues of rats. In addition, reduced glutathione (GSH) content of liver and kidney tissue homogenates significantly decreased. The biochemical results were confirmed by histological findings where many lesions were noticed in liver and kidneys treated with cadmium. Administration of lipoic acid with cadmium chloride showed a significant improvement in the above parameters and histopathological pictures. Conclusion: The present study concluded that the supplementation with 100 mg kg–1 b.wt., of lipoic acid is effective against cadmium toxicity. It is advisable to give it to workers in cement factories.