Abstract: Background and Objective: This study was conducted to investigate the factors influencing the adoption of telehealth systems by hospital staff. Specifically, perceived risk, computer self-efficacy and the technology acceptance model were incorporated into a theoretical model that explains and predicts the behavioral intentions of users operating a telehealth system. Materials and Methods: This study obtained data from hard copy survey responses to self-report questionnaires administered to staff at a hospital in Taoyuan, Taiwan. This study distributed 1,100 questionnaires of which 1,068 were retrieved. After invalid responses were removed, 1,018 questionnaires remained, yielding an effective retrieval rate of 93.7%. Using structural equation modeling (SEM). Results: The results showed that the perceived risk negatively affected perceived usefulness, computer self-efficacy positively affected perceived usefulness and perceived ease of use, perceived usefulness positively affected perceived ease of use; perceived usefulness and perceived ease of use positively affected attitude and attitude positively affected behavioral intention. The path coefficients of perceived risk on perceived ease of use were non significant (p>0.05). Conclusion: The study contributes to the application of health care systems in hospitals by investigating multiple variables. The findings may assist hospitals in consider which information technology to invest in when implementing a new telehealth system.