Abstract: Background and Objective: Morin is a natural yellow compound that is scientifically proven to have pharmacological activities including hypoglycemia, inflammation and anti-oxidative. The aim of the present study was to evaluate the anti-dyslipidemic, antioxidant and anti-inflammatory effects of morin in high cholesterol diet (HCD) fed rats. Materials and Methods: High cholesterol diet (HCD) in pellet form was prepared by adding 1% cholesterol+0.5% cholic acid in rat chow powder and fed male Wistar rats for 6 weeks. Morin with three different doses (25, 50 and 100 mg kg–1, orally) were treated to HCD fed rats for 4 weeks further feeding HCD. In serum, lipid profile, liver enzymes, renal markers tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), Interleukin-1β (IL-1β), caspase-3, nitric oxide (NO) and nuclear factor kappa-B (NF-κB) levels were estimated. In renal and hepatic cells, thiobarbituric acid-reactive substance (TBARS), glutathione (GSH), Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx) and glutathione-S-transferase (GST) activities were measured. Results: Animals exposed to a HCD exhibited significant increases in serum lipid profile, liver enzymes, renal markers, interleukins, caspase-3, NO and NF-κB levels. Morin supplementation reversed these changes towards normal levels in a dose-dependent manner. The HCD feedings significantly altered the oxidative stress biomarkers TBARS, GSH, SOD, CAT, GST and GPx in hepatic and renal tissues. Four weeks of morin treatment with three different doses (25, 50 and 100 mg kg–1 day–1) to hypercholesterolemic rats significantly reversed oxidative stress levels in liver and kidney tissues in a dose-dependent manner. Conclusion: Morin exhibited inhibitory effect against HCD-induced hepatic and renal damages by inhibiting oxidative and inflammatory progressions. Thus, it could be considered as a potential alternative therapeutic agent for management of hypercholesterolemia.