Abstract: Background and Objective: Cotton is an important commercial crop cultivated in India for its raw fiber to meet the demand of textile industry. Cotton is a wide spaced slow growing crop initially and consequently vulnerable for weed infestation. Development of appropriate intercropping system will curtail the weed problem and in addition with nutrient management will increase the yield of cotton. Therefore, the field experiment on evaluation of suitable intercrop and nutrient management on weed control and seed cotton yield was carried out. Materials and Methods: The experiments were laid out in a split plot design with three replications. Intercropping system viz., C1: Cotton sole, C2: Cotton+Blackgram, C3: Cotton+Greengram and C4: Cotton+Cluster bean were allotted to main plot. The intercrops residues were incorporated at 65 DAS. The sub-plot consisted of 6 treatments viz., N1: 100% RDF (Recommended dose of fertilizer: 80:40:40 kg NPK/ha), N2: 75% RDF, N3: 75% RDF+biofertilizers, N4: 75% RDF+5% Morinda leaf extract spray, N5: 75% RDF+5% Vilvam leaf extract spray, N6: 75% RDF+5% Annona leaf extract spray. Results: Intercropping system established significant smothering effect in controlling weeds combined with nutrient management. Among the different intercropping system and nutrient management, cotton+blackgram intercropping with integrated nutrient management involving application of 75% RDF+seed treatment and soil application of biofertilizers recorded low weed density and higher seed cotton yield (1619 and 1715 kg ha–1 during winter 2007 and Summer 2007-2008, respectively). Conclusion: Cotton+blackgram intercropping system with application of 75% RDF+seed treatment and soil application biofertilizers may be recommended for weed smothering and for obtaining higher seed cotton yield.