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Journal of Applied Sciences

Year: 2019 | Volume: 19 | Issue: 3 | Page No.: 235-240
DOI: 10.3923/jas.2019.235.240
Antifungal Activity of Parkia biglobosa Extract on Pathogenic Strain of Candida albicans
Usman Yahaya , Samiratu Abubakar and Aminu Salisu

Abstract: Background and Objective: Medicinal plants play an important role in the development of potent therapeutic agents. Parkia biglobosa is a plant used in traditional medicine for the treatment of certain diseases. In order to scientifically apprise some of the medical uses of parkia biglobosa, this study aimed at making phytochemical screening and evaluating some anti-fungal activities of P. biglobosa leaves and bark extracts. Materials and Methods: Two different extracts (ethanol and aqueous) of dried leaf of Parkia biglobosa were tested against pathogenic strain of Candida albicans. Phytochemical screening, minimum inhibitory concentration (MIC) values and minimum fungicidal concentration (MFC) values of the plant extracts were determined. Results: The major phytochemical constituent of interests such as alkaloids, glycosides and saponins are found to be present in the both aqueous and ethanolic extracts of bark and leaves of Parkia biglobosa. Aqueous bark extract of Parkia biglobosa produced the highest zone of inhibition of 11.60±0.58 at concentration of 50 mg mL–1 which surpassed nystatin (500 IU mL–1) with zone of inhibition of 9.33±0.58. The lowest zone of inhibition of 1.03±0.08 was obtained by ethanolic leaves extract at concentration of 2.5 mg mL–1. Conclusion: The fungi toxicity tests have shown that extracts from leaves and bark of Parkia biglobosa at concentration of 50 mg mL–1 can replace synthetic drugs in the management of intertrigo infection.

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How to cite this article
Usman Yahaya, Samiratu Abubakar and Aminu Salisu, 2019. Antifungal Activity of Parkia biglobosa Extract on Pathogenic Strain of Candida albicans. Journal of Applied Sciences, 19: 235-240.

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