Abstract: Background and Objective: Ficus capensis is one of the plants used in folklore medicine in Nigeria, for the treatment of various disease conditions and promotion of vascular health. This study was undertaken to investigate its cardioprotective potential against carbontetrachloride (CCl4)-induced myocardial necrosis in rats. Materials and Methods:Albino rats were divided into four main groups: normal control, CCl4 control, 1.2 mg kg–1 b.wt., aspirin pre-treated and Ficus capensis extract pre-treated groups. Extract was administered orally at doses of 100, 200, 300 and 400 mg kg–1 b.wt., for 7 days to evaluate their effect on CCl4-induced cardiotoxicity. Aspirin was used as standard drug. On day 7, cardiotoxicity was induced in animals of CCl4 control, aspirin and extract pre-treatment groups. Histopathological examination was performed to evaluate the basic action of extract and statistical differences were assessed using one-way ANOVA and Duncan's multiple range test with SPSS version 22.0. Results: CCl4 intoxication in CCl4 treated rats caused significant (p<0.05) increases in serum contents of cardiac biomarker enzymes and raise in lipid peroxidation whereas significant (p<0.05) decreases in cardiac enzymatic antioxidant and glutathione reductase contents were observed when compared to normal control. Pre-treatment with Ficus capensis stem bark extract expressed cardioprotective ability against CCl4-induced oxidative changes in myocardium by significantly (p<0.05) altering levels of cardiac biomarker enzymes towards normal, enhancing the activity of suppressed antioxidant enzymes and lessening lipid peroxidation level. Histopathological examination of cardiac tissues, following extract pre-treatment showed correlation with serological studies. Conclusion: Based on these findings, Ficus capensis stem bark is potent against CCl4-induced oxidative stress in heart due to its antioxidant and cell stabilization property.