Abstract: Objective: The objective of study was to create digester (reactor) design by using the Upflow Anaerobic Sludge Blanket (UASB) technology for manure handling to produce household-scale biogas. Methodology: The digester consisted of a plastic tank with three rooms. There was the main room, the second room and the gas-solid separator or cross-section room. The volume of the digester was 179 L. The hydraulic retention time was 20 days. It was conducted in two phases: batch phase for 20 days and continuous phase for 21 days. Results: During the batch phase, the average discharge of Total Suspended Solids (TSS) were 4856.67 mg L–1, Volatile Suspended Solids (VSS) were 8520 mg L–1 and Chemical Oxygen Demand (COD) was 14911 mg L–1. During the continuous phase the average discharge of TSS were 13374.29 mg L–1, VSS were 26642.86 mg L–1 and COD were 41653.57 mg L–1. The removal efficiency of TSS, VSS and COD during the batch phase were 55.4, 79.8 and 17.4%, respectively, while this did not occur during the continuous phase. The biogas production began to increase at the beginning and during the continuous phase. The continuous phase had a higher average of biogas production than the batch phase. The highest speed of biogas production occurred at 8 am to 12 pm with a temperature of 34.97±3.18°C and pH of 5.67±0.04. The average volume of biogas production per day during the batch phase was 2,534 mL and during the continuous phase was 22,519.05 mL. Methane content in the biogas on day 10, 21, 30 and 41 were 2.65; 38.12; 78.99 and 76.97% mol, respectively. Sedimentation occurred during the batch phase while the continuous phase had no sedimentation at all. Conclusion: The implementation of UASB design to process cow manure by handling to produce household-scale biogas had the advantages of upward flow, a gas-solid separator and the sedimentation process. The upflow and gas-solid separator has the roles to help remove and separate the biogas bubble from the sludge’s solids and liquids and the highest methane content during production achieved in the continuous phase. It can be applied efficiency and massively to manage livestock waste in household-scale in remote areas, especially in disadvantaged villages.