Abstract: Results concerning a telemetric multi-sensor measuring station, monitoring six physico-chemical thermal water parameters are reported. The system at its final fully operational stage is capable to continuously measure, transmit and process data. It is located in Greece at Thermopylae hot spring. Τhe study presents a statistical time series analysis for all factors. It further tries to explore if there are some signals that can be considered as precursors to local seismic activity. Some interesting outcomes of the work include emerging periodicities and statistically significant correlations between the involved physico-chemical variables. An important finding is the appearance of six radon anomalies that could be precursor signals to posterior seismic activity. It is the first time that water radon anomalies from seismic activity in Greece have been analyzed.