Abstract: In the process of coal seam pulse water infusion, liquid-solid coupling effect exists in coal seam between the stress field and seepage field. Based on the basic principle of liquid-solid coupling, the dynamic liquid-solid coupling effect of stress and seepage field during coal seam pulse water infusion is simulated through secondary development of ABAQUS software, during this process the mathematical model of the strain accumulation model due to the periodic changes of pulse water pressure is embedded in SOIL module of ABAQUS software. The law of different parameters of pulse water infusion on the permeability of coal around the infusion hole is gotten. Numerical simulation results show that, during the process of coal seam high pressure pulse water infusion, the stress field and flow field are mutual influence and mutual restriction. The coupling of the stress and flow field have impact on the physical and mechanical properties of coal in front of the working face, these factors promote each other and preventing coal and gas outburst effectively. The permeability of coal increase significantly with the water infusion time prolong under constant water infusion pressure and frequency. The permeability of coal increase significantly with the water infusion pressure improving under constant water infusion time and frequency. The permeability of coal increase significantly with the water infusion frequency improving under constant water infusion pressure and time. So the pulse water infusion time needs to ensure a better effect of preventing coal and gas outburst is gotten. Meanwhile the high pressure pulse water infusion pressure needs to improve under the existing technical conditions and not cause big coal fissure. The frequency of pulse water infusion needs to improve under the existing technical conditions. This research results have great theoretical value and practical significance on revealing the mechanism of coal seam pulse water infusion on permeability, enhancing the validity of the technological parameters design in coal seam water infusion and implementing the technology in the site.