Abstract: This study evaluated the potential of Rhazya stricta L. growing on a surrounding area of the second industrial zone (24°39.8’ N; 46°57’ E), east of Riyadh, Saudi Arabia. Plant and the associated soil samples were collected and analyzed for total Cr, Fe, Ni, Cu, Zn, Cd and Pb concentration. The degree of contamination by those heavy metals in soil and transfer to Rhazya stricta has been estimated. The results showed a medium contamination of soil heavy metal content with respect to Cd and Pb. The total concentration of Fe, Cr, Ni, Zn and Cu in shoots of Rhazya stricta was 275, 5.30, 10.5, 27.5 and 8.30 mg kg-1, respectively. On the other hand, the total concentration of heavy metals in the roots was as follows (mg kg-1): Fe: 0.1; Cr: 0.5; Ni: 3.0; Zn: 0.8 and Cu: 1.6. Heavy metals (Cr, Ni, Cu and Zn) tended to be accumulated in the roots Rhazya stricta rather than the stems and leaves expect for Zn. The calculated accumulation coefficient of heavy metals in the roots was higher than that in stems or leaves. The Rhazya stricta plant exhibiting Translocation Factor (TF) values less than one except for total Zn (1.10-1.60). The results indicated that, Rhazya stricta plant could not suitable for heavy metals extraction from the contaminated studied soil but can be used as an indicator for soil contamination with some heavy metals (Cd, Cu, Pb and Zn) and also to minimize heavy metals mobility in contaminated soils.