Abstract: Inter-domain analysis and studies are growing rapidly, which is fruitful in improving the efficient usage of individual field. This analysis embeds Opinion Mining in Cloud Computing and Field programmable Gate Array (FPGA). The explosion of social networks and blogs provide a new set of issues and openings by means of information searching and retrieval. These opinions play major role in influencing everything, such as purchase of product, availing service also even the presidential candidate that the people support. One of the proposed modules is having opinion mining tool to process the opinion corpus. Organizations can use this to determine user’s perception about their products and competitors and consumers can get decision about products. Though many researchers have developed these types of tools, their accessibility is limited and corpus size is small. Keeping in mind, the objective of this study is to combine domains and thereby increasing the effective utilization of tool, the proposed framework is implemented globally in a cloud network. Besides this, cloud provides services such as storage, communication and computation. Since cloud has the capability to process large volume of data at a time, it need to increase the speed in storage, retrieval and process. Here comes the domain FPGA which solves this issue and fasten the service usage and provision.