Abstract: An examination of electrocrystallized L-Isoleucine solubility and the resulting crystals produced following the solubility pattern is presented in this study. The data in this study is compared with previous study without the influence of electric potential and it is revealed that under the influence of electric potential, the solubility of L-Isoleucine decreases as the electric potential increases. The solubility also is proven to be negatively deviated from ideal system. The plot of van’t Hoff solubility data suggested decreasing of transition temperature of L-isoleucine polymorph with increasing electric potential applied to the solution. The polymorphs produced are found to be enantiotropically related even when electric potentials were applied to the solution. It is also suggested the L-isoleucine molecules arrangement in solution has become more ordered as the electric potentials were increased.