Abstract: This study gives comparative analysis on the internal mechanism and historical context of the mixed-use habitation mode of China from two aspects of time and space. Through the feature analysis and mode comparison of the mixed space in different regions and units, the study attempts to discuss the diversity of the settlement organization and habitation paradigm of work-live mixture with the discussion of the construction development law of the mixed-use habitation paradigm in the Yangtze River Delta region, so as to build the mixed-use habitation mode with regional features.