Abstract: This study designs and optimizes a multi-level dairy logistics distribution system based on hybrid genetic algorithm to satisfy the distribution in large area. Firstly a Logistics center is built near the factory and a distribution center is built near the customer. And an optimization model of tshe dairy logistics distribution system is established by considering the reliability and the cost of the distribution service level. Then the hybrid genetic algorithm is proposed according to the specialty of the optimization model. Finally, a numerical example is given, the results of a numerical example show that the given algorithm is valid for the large-scale logistics network optimization model.