Abstract: A number of protocols have been proposed so far to tackle node replication attacks. However, none of these schemes are suitable for wireless sensor networks with mobile nodes. Based on the collaboration mechanism of static and mobile nodes, a multi-point collaboration detection scheme against replication attacks is proposed. The scheme is consist of a polynomial based time-identity related pairwise key predistribution scheme (PTPP) which is used to defend the static network and a challenge/response based collaborative detection scheme (CCD) which is proposed for the detection of mobile replicas. A collaborative detection system is designed on GAINS3 platform. The experiment result shows that the scheme has good performances in embedability and practicality.