Abstract: Discusses supply chain information system alignment and supply chain integration on the mediation of the relationship of environmental uncertainty and supply chain growth, using structural equation model to empirical analysis on the related theoretical assumptions. The empirical results show that environmental uncertainty for supply chain growth has significant positive action; Supply chain information system alignment is the partial intermediary of the positive relationship of environmental uncertainty and supply chain growth; Supply chain integration is the partial intermediary of the positive relationship of environmental uncertainty and supply chain growth. Research conclusion for understanding the environment uncertainty, building supply chain information system alignment, promoting supply chain integration, achieving supply chain growth has a guiding meaning and reference value.