Abstract: Long pulsed laser ablation was applied to synthesis Bi0.6Sb1.4Te3 nano-sized particles of corresponding bulk target in argon environment. Normally, short laser pulses, nanosecond or less, have been used. This work involves with an economical technique involving a Nd:YAG laser working at 1064 nm and millisecond long pulses. System operating parameters including laser frequency (1 Hz), pulse duration variation (1, 3, 5 msec) and target speed at 3000 rpm (2.2 m sec-1) were held constant. The particles produced by laser ablation have been characterized by scanning electron microscopy and X-ray diffraction for the morphology and the crystallographic structure of the nano-particles. The experiment shows that the particles were produced in the form of aggregates of primary particle in the nanometer size range between 20 and 120 nm depend on irradiation laser fluence. This technique can prepare mass production of nano-particles in a very short time when compare to femtosecond or nanosecond laser.