Abstract: This study was conducted to retrospectively evaluate the accuracy and performance of ultrasonography in detection of intussusception as well as to prevent unnecessary surgery. Between May 2007 to December 2008, 54 patients with suspected intussusception underwent screening ultrasonography. The mean age of the patients was 2.7 years. Patients were divided into groups according to age and gender. Out of 54 patients, 27 had negative ultrasonographic results and the rest 27 had positive results. Out of 27 patients who had a negative ultrasonographic result, 26 patients had a correct ultrasonographic results and one has no intussusception was evident on air enema. Among those 26 patients, in 21 (96.2%) patients air enema was positive for intussusception (true negative) and in 5 (3.7%) patients surgery were positive for intussusception (false negative). Twenty-seven patients had a positive ultrasonographic result; 25 (92.5%) (True positive) were confirmed by air enema and 2 (7.4%) intussusception were confirmed by surgery (false positive). The total accuracy rate was 94.4%, sensitivity was 92.5%, specificity was 96.2%, positive predictive value was 96.1% and negative predictive value was 92.8%. Accuracy of ultrasonography in screening for suspected intussusception is high and has gained both the respect and confidence of the pediatricians. However, sonographically guided hydrostatic reduction of childhood intussusception is a simple, safe and very successful technique that does not expose the child to ionizing radiation and can in many cases replace operative management.