Abstract: The aim of this study is to evaluate the growth response of Leucaena leucocephala inoculated with Glomus intrarradices and application of organic matter and the actual level of contamination with heavy metals Cu, Cr, Zn and Pb in soil irrigated with sewage and clean water. Sewage water is used for irrigation, which creates both opportunities and problems. This is an option to reduce the stress on limited fresh water and help meet the nutrient requirement of crops, but also produces contamination. In the irrigation District 018, Tulancingo, Hidalgo, Mexico, forage for cattle has been irrigated with residual water for several years. To evaluate the level of contamination of two plots, one hectare was irrigated with residual water and another with clean water. In soil the contamination of Cu, Cr and Ni are below the established limits for contaminants. Pb was not found. A comparison of soil irrigated with clean water or sewage water indicated that Cu is nearly twice as concentrated in soil irrigated by contaminated water; Ni is slightly greater; Cr is more abundant. Soil was collected for a greenhouse experiment with Leucaena leucocephala (guaje) to observe its growth with inoculation of Glomus intrarradices with different amounts of vermicompost. Later a factorial experiment 7x2 completely randomized design with five replications in the greenhouse was established. The variables measured were plant height, stem diameter, root volume, dry weight of biomass and dry weight of roots. The experiment lasted 180 days from planting until harvesting. It is concluded that the inoculation with Glomus intrarradices increased the absorption by Leucaena leucocephala in nutrient adsorption.