Abstract: Two types of electrochemical sensor were introduced for the selective determination of dopamine. Both potassium tetrakis-[3,5-bis-(trifloromethyl)-phenyl] borate (K-TFPB) and a synthesized N,N-bis-ethoxycarbonyl-1,10-diaza-4,7,13,16-tetraoxacyclo-octadecane (DZCE) were used as charged ionophore and a neutral carrier. The calibration graphs of the obtained electrodes showed satisfactory Nernstian slopes (57.8 and 58.4 mV/decade). The optimum pH value was 3.5-8.3 for both electrodes. Selectivity coefficients of the studied electrodes were calculated towards several inorganic cations, aminoacids and pharmaceutical compounds. The Relative Selectivity Coefficient (RSC) was introduced and was applied for evaluating the selectivity properties of dopamine electrode using Zareh`s equation. Average Relative Selectivity Coefficient (ARSC) and Total Average Relative Selectivity Coefficient (TARSC) were defined and calculated as new parameters for each electrode. An improvement of the selectivity coefficient values was observed when (DZCE) was added as neutral carrier to the membrane constituents. The electrode was applied for the determination of dopamine in its pharmaceutical preparations.