Abstract: A survey of the gross alpha and beta radionuclide activity of Okpare Creek in Delta state has been carried out. Twenty samples of the creek water were collected from the farming, residential/commercial and industrial zones along the creek and were analyzed using the eurysis system-eight-channels-gas-filled proportional counters. The count results show that the average alpha activities in the farming, residential/commercial and industrial zones are 1.003±0.097, 4.261±0.109 and 10.296±0.489 Bq L-1, respectively. The average beta activities in the three zones are 0.129±0.100, 0.523±0.003 and 0.793±0.010 Bq L-1, respectively. The overall results show that the alpha and beta activities in the three zones are far below the practical screening levels of radioactivity in drinking water of 100 Bq L-1 for alpha and 100 Bq L-1 for beta recommended by CEC-FAO and WHO and therefore may not pose any serious detrimental health side-effects to the public users of the creek.