Abstract: In this study, the influence of the orthopedic screws engineering design such as profile shape and geometrical parameters on its biomechanical compatibility in terms of load sharing with adjacent bone tissue was investigated. The study was conducted on a set of three-dimensional finite element design models. A dimension less Stress Transfer Parameter (STP) was utilized for gauging the performances of the different screws according to its load sharing capabilities. Stress-transfer behavior was found to be linear for varying load magnitudes. The geometric properties investigated; pitch, thread length, width, major diameter and thread angle showed different influences on the three different profiles studied (triangular, trapezoidal and rectangular). The results indicated that 13 out of 32 screw designs produced were to achieve STP values greater than 0.3 of these, 6 were the rectangular profile. The best design was of the rectangular profile (Design no. 24) with an STP value of 0.4344. It was concluded that the best biomechanical properties were found in rectangular screw profiles. However, due to mix trends for the different properties, the careful combination and consideration towards pullout strength was necessary to obtain a design with the highest biocompatibility.