Abstract: The main objective of the present study is to investigate factors that contribute significantly to enhancing the risk of ischemic heart disease. The dependent variable of the study is diagnosis - whether the patient has the disease or does not have the disease. Logistic regression analysis is applied for exploring the factors affecting the disease. The result of the study show the factors that contribute significantly to enhancing the risk of ischemic heart disease are the use of banaspati ghee, living in urban area, high cholesterol level, age group of 51 to 60 years. Other significant factors are Apo Protein A, Apo Protein B, cholesterol level, high density Lipo protein, low density Lipo protein, phospholipids, total lipid and uric acid.