Abstract: Mathematical models are the best tools available for prediction purpose in the field of air quality management. In the present study a Gaussian Plume Model is developed to determine the concentration of pollutants from point source emissions. The model is applied to the Industrial zone of Manali region, Chennai. Based on the emission inventory, Meteorological parameters, the concentration of SO2 is determined for three different seasons. Three months of wind speed, wind direction and cloud cover data recorded by India Meteorological Department (IMD) were used for concentration computations. The computed concentrations were compared with the observed concentration in the study area. The statistical evaluation of the model indicates satisfactory performance. Comparison of numerical result with observed data showed a marked seasonal trend along the study period, which is characterized by high levels of SO2 in winter and decreased progressively through the, monsoon and summer seasons.