Abstract: Thirteen safflower mutants along with parental varieties and Mexican Lines were studied for variability, heritability, genetic advance and coheritability in irrigated and drought stress condition. Genotypic and phenotypic variances were highest for height and number of seed in capitulum. Whereas the maximum genotypic and phenotypic coefficients of variability were found in number of capitulum and number of seed in capitulum. Heritability estimates ranged from very low to high. Maximum heritability of 0/94 in irrigated condition was obtained for 100 seed weight and 0/711 in drought condition was obtained for capitulum diameter. In irrigated condition high heritability for capitulum weight, days to 50% flowering and days to maturity and in drought stress condition for number of seed in capitulum, days to 50% flowering and days to maturity with high genetic advances was obtained that these traits could be improved through mass selection. Coheritability estimates indicated that in irrigated condition selection for 100 grain weight, capitulum weight, number of seed in capitulum and in drought stress condition selection for stem diameter, capitulum diameter, 100 seed weight and number of seed in capitulum would improve the yield.