Abstract: In this study, aiming to the problem of poor precision of localization or mistaken detection suffering from the influence of the noise and the burying status of observable spot through the negative pressure wave detection, especially, under the condition of leakage multi-source, we often find the phenomena of mistaken detection. To improve the precision and correctness of localization, we propose a kind of information fusion technology used to detect the leakage of water pipeline. Here firstly we adopted the clustering method of ISODATA (Iterative Self-Organization Data Analysis Techniques Algorithm) to classify the leakage multi-source and then give a more precise localization with the weighted average method to integrate the information from every leakage source. At last, an example is illustrated to testify the validity of this method.