Abstract: The influence of ignition manner on micropyretic synthesis of low exothermic reaction with Ni+Al is numerically investigated in this study. The different ignition powers and ignition regions are chosen to illustrate the influences on the length of pre-heating zone and propagation velocity of the specimens. The numerical results indicate that a lower ignition power or igniting in the center region accelerates the heat loss. Thus, the length of pre-heating zone is increased and the average propagation velocity is correspondingly decreased. In the extreme case, the combustion front may not complete the propagation for the reaction with a lower pre-exponential factor. In addition, it is also shown that a higher ignition power consumes the additional ignition energy to ignite the specimens. Such an increase in the required ignition energy enhances the processing cost, but also probably results in the unstable propagation. The optimal ignition manner for micropyretic synthesis of Ni+Al reaction is generated in this research.