Abstract: The experiment was carried at Student’s Experimental Farm, Sindh Agriculture University Tandojam, Pakistan on post emergence weed control in wheat. It was noted that most of the weeds present in wheat were broad leaved weeds, whereas narrow leaved grasses and sedges were in small number. With the application of herbicides though the number of weeds of all species decreased but in most of the cases their intensity increased. All the growth, yield and yield parameters increased with the application of herbicides as compared to un-weeded plots. The additional yield (49.98%) was exhibited with the application of Topik 240WP at 250 g ha–1 herbicide followed by Arelon 50 dispersion at 0.75 l ha–1, which increased 43.74% grain yield. It is concluded that weeds reduce the economic yield by competing for nutrients, light and moisture. The cost and maintenance of cultivation are increased and soil fertility is degraded due to weed problem. Thus, it is prime important to control weeds and an increase in the yield up to 50% or more can be achieved.