Abstract: The prime objective of the study was to investigate the role of non government organization (Ali Foundation) in improving socio-economic and physical condition of the patients of thalassemia and hemophilia the study was examine the problems faced by the patients. 100 respondents were selected from Ali foundation. Well designed questionnaire consisting of structured as well as nonstructured questionnaire was used in this study we explore the research objective. The appropriate statistical techniques such as descriptive and inferential statistics were used for data analysis.