Abstract: Field experiments were conducted in 2002 and 2003 at the Teaching and Research Farm of the University of Ibadan and the Experimental field of the National Horticultural Research Institute, Ibadan, Nigeria, to assess the effects of different sources of nitrogen on the yield and nutritive value of Solanun macrocarpon. The experiment was a randomized complete block design, replicated three times. Results showed that nitrogen differed significantly in their ability to increase edible yield, stem and the economic yield at both years of study. Economic yield increase of 21.7, 46.8 and 53.3% were obtained using inorganic, organomineral and poultry manure respectively, in 2002 and the corresponding values for 2003 are 59.6, 50.2 and 43.2%. Results indicated no significant differences for most nutrient content at both years of study except for moisture content, protein and ash in 2003. The study highlighted the potential of poultry manure as well as organomineral fertilizers in vegetable production especially for Solanum macrocarpon in Nigeria.