Abstract: A field experiment was carried out at Nahshala Farm, about 50 km from Al-Ain, UAE during the 2001/2002 growing seasons, using five halophyte species; Spartina sp., Distichlis palmeri., Paspalum vaginatum, Juncus roemerianus and Batis maritima, under six levels of N and K fertilizer combinations irrigated with salinity water of 20 g L-1. The objectives of the experiment were twofold; 1) to find out the optimum rate of potassium and nitrogen under such high salinity stress and 2) to study the response (growth and biomass production) of such halophytes to different levels of K and N as an anti-salinity nutrients. The experiment was conducted in triplicate with a split-plot design arranged in randomized complete block. Results indicate that controlling soil fertility especially N and K under saline soils condition is considered one of the most important factors in order to conduct reliable study on the evaluation of tolerance of plants to salinity stress. Nitrogen and potassium proved to increase plant salt tolerance to produce high biomass. This study also supports the idea of using high saline water of about 20 g L-1 salt concentration in agriculture along with N and K fertilizers accompanied with increasing leaching fraction to maintain satisfactory yield production of such halophytes.