Abstract: In the present study, a multi-layer perception neural network and Radial Basis Function (RBF) network were used to model of extract form lotus seed liquor lees of furfural content. Artificial neural network were used to model extract furfural from lotus seed liquor lees and comparison with the results obtained from a regression analysis. Owing to the furfural in lotus seed liquor was easy to mix with organic matter in any proportion. The appropriate extraction conditions guaranteed the maximum extract from lotus seed liquor lees. This study provided a theoretical basis for the production of liquor.