Abstract: To solve the problem of partnership choice of Supply Chain in the context of 3D Printing and Big Data, a method to choose cooperative partners based on Analytic Hierarchy Process and Fuzzy Synthetic Evaluation was proposed. Analytic Hierarchy Process was used to construct the hierarchical structure of partner evaluating indicator and determine the corresponding weight. Fuzzy Synthetic Evaluation was adopted to assess and choose partners. For verifying the method, a logistics company was analyzed as an example. The results show that this method may reduce the influence of subjective factors on the partner choice, enhance the accuracy and reliability of partner choice and strengthen the competitiveness of supply chain enterprises.