Abstract: The generalized multi-carrier (GMC) is a new type of broadband wireless multiple access technique, where the modulation and demodulation filter bank played an important role. This study investigated the interference of the GMC system with the modulation/demodulation filter bank and the close-form interference expression was obtained in terms of the inter-carrier interference and the inter-symbol interference. Moreover, three different kinds of prototype filters, named Rcosine, Remez and Nyq2, were simulated to show the influence of filter type on the interference, where both the infinite precision calculation and the finite precision computation were employed. The result shows that the interference performance would be limited by the filter delay, the quantization word length and the filter type.