Abstract: A novel full-duplex SSB-RoF system with 16 QAM-OFDM bidirectional links was proposed. Because the configurations of the used transmitters and receivers at the central office and base station are same, the BER curves were similar for back-to-back case. The results demonstrated, after transmission over 41 km SSMF-28, the OSNR value of the received downlink signal was 10.5 dB at BER = 10-3 which was slightly lower than the OSNR value of the upstream signal. Hence, 16 QAM-OFDM signals could be transmitted successfully over 41 km SSMF-28 for downlink and uplink application. It would be a competitive scheme for bidirectional 16 QAM-OFDM signals application in future RoF systems.