Abstract: Virtual Classroom (VC) not only has the function to replace a traditional classroom but also has less expense related to transportation, building new facilities, or the maintenance or repair of existing facilities. This study proposes some factors which influence the success of E-teaching. The subjects include students who have experience of attending related e-teaching system. Data were collected on May 2010. Subjects were in age from 18-24 years old. SPSS Amos 18 is used for data analysis and it shows that government policy, school regulation, student experience are important roles in guiding a successful e-teaching activity. This study also confirms that User Experience is the most significant determinant that directly affects the effect of user interaction and knowledge exchange in e-teaching practice. When users get greater experience of IT operation skill, their feelings about E-teaching practice will be more successful. The adoption of E-teaching would be more successful when users gain greater skills at IT operation. Fulfilled E-classroom application is able to help the elite or mass stage of higher education system moving to the universal stage because per student cost of VC is quite lower. The suggestion of E-classroom implementation is also helpful for the expansion of higher education in some countries, such as Asian countries (China, Mongolia, Thailand, the Philippines and Indonesia) or other elite stage countries.