Abstract: In this study, the problem of Fault-Tolerant Control (FTC) for a class of uncertain nonlinear systems is studied. A novel FTC scheme is proposed to deal with both lock-in-place and loss of effectiveness faults of actuators. By employing fuzzy approximation and on-line adaptive updating, the proposed control scheme can tolerate the faults without detection and diagnosis mechanism. It is proved in theory that the FTC scheme can guarantee the closed-loop stability and desired output tracking performance in spite of all kinds of the faults and external disturbances. A simulation example is also included to show the effectiveness of the scheme.