Abstract: In multi-cell multi-antennas networks with uplink training, the channel estimate at the base station in one cell jammed by users from other cells, the performance of systems suffers tremendous losses due to the use of corrupted pilots. In addition, as the MMSE precoding matrix exists singularity problem when coordinative method is used, The goal is to investigate precoding techniques for downlink transmission to mitigate this corruption and thus increase achievable rates. A multi-cell MMSE precoding depending on the pilots assigned to the users is proposed, which does not need coordination. This precoding is the optimal solution of an optimization problem, which consists of the mean-square error of signals and the mean-square interference. Simulation results show that this precoding method can effectively reduce intra/inter-cell interference.