Abstract: Focusing on the problem of fault detection and isolation (FDI) for a missile in the cruise phase, a solution based on Linear Parameter Varying (LPV) Fault Detection Filter (FDF) is proposed. The missile LPV model incorporating faults is established and converted to a suitable form for the appliance of LPV, FDI via simplifying and other tools. Based on that, a fault detection system of missile is proposed for fault detection and isolation, of which the LPV filter bank can be designed using standard geometrical approach. Simulation results demonstrate that the designed fault detection system will alarm in a short time once faults happen and then locate the fault part correctly. Since the designed fault detection system is suitable for the high maneuverability of the missile and the on-line calculation load is small, the solution is of great practical value.