International Journal of Virology

Year: 2006 | Volume: 2 | Issue: 1 | Page No.: 25-34
DOI: 10.3923/ijv.2006.25.34

Synthesis and In vitro Anti-HIV-1 Activity of Electrochemically Reduced Praseodymium Salts of 12-tungstophosphate Acid

Yanyong Liu, Shuxia Liu, Enbo Wang, Yi Zeng and Zelin Li

Abstract: A praseodymium salt of 12-tungstophosphate acid, Pr[PW₁₂O₄₀], was synthesized using ion exchange and double decomposition method. Then its 2e and 4e electrochemically reduced heteropoly blues, PrH₂[PW^VI₁₀W^V₂O₄₀] and PrH₄[PW^VI₈W^V₄O₄₀], were synthesized using control-potential electrolysis reduction method. These compounds were characterized with FT-IR, UV-vis, polarography, ESR and XPS. The α-Keggin type structure was kept in the heteropoly blues PrH₂[PW^VI₁₀W^V₂O₄₀] and PrH₄[PW^VI₈W^V₄O₄₀] but the electronic density of heteropoly anion increased after electrochemically reduction. Heteropoly blues PrH₂[PW^VI₁₀W^V₂O₄₀] and PrH₄[PW^VI₈W^V₄O₄₀] showed relatively high in vitro anti-HIV-1 activity and relatively low cytotoxicity on MT-4 cells compared to some other anti-HIV-1 compounds. Because heteropoly blues possess higher negative electronic charges than their non-reduced parents, they strongly interact with HIV-1, MT-4 cells and macrophages and effectively suppress fusion, infection and proliferation of HIV-1.