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International Journal of Virology

Year: 2005 | Volume: 1 | Issue: 1 | Page No.: 65-65
DOI: 10.3923/ijv.2005.65.65
Assessment of Hepatitis E Viral Infection and Its Effect on Egyptian Pregnant Mothers
Abo-Elkhier A.A-E., , Abdel-Wahab K.S.E., , Ali M.A., , El-Sayed M.A-H., , Saleh. N.A-K., and Atef A.A.

Abstract: A 120 aborted women between 17-49 years old and 120 women aged matched who had normal full term pregnancy in labor were included in the present study. Maternal blood was tested for anti-HEV IgG and IgM antibody and the positive cases were tested for HEV Ag and HEV RNA. The fetal tissue from anti-HEV IgG and IgM positive aborted women and cord serum of infant of anti-HEV IgG and IgM positive full term delivered women were tested for HEV Ag and HEV RNA. Among 120 aborted women, 2.5 % (3/120) 0f them were positive result with anti-HEV IgM, anti-HEV IgG, HEV RNA and HEV Ag, also 11.7 % (14/120) of them gave positive result with anti-HEV IgG, HEV RNA and HEV Ag, and 5.8 % (7/120) of them were positive for anti-HEV IgG only. Also 13 of 120 (10.83 %) full term delivered women were anti-HEV IgG positive only. All results of liver function tests of HEV-RNA positive aborted women appeared to be slightly higher than of HEV RNA negative aborted women, these differences was statistically significant (P < 0.05) (Except total protein and alkaline phosphatase). It was found that 3 anti-HEV IgM, anti-HEV IgG, HEV RNA and HEV Ag positive pregnant women transmitted the virus to their all fetus (100 %), While 14 anti-HEV IgG, HEV RNA and HEV Ag positive pregnant women transmitted the virus to 12 (85.7 %) of their fetus and the fetus died and terminated to abortion. However the 7 anti-HEV IgG positive aborted women did not transmitted the infection to their fetus. Also the cord serum of infant of 13 anti-HEV IgG positive full term delivered women gave negative result with HEV-RNA.

How to cite this article
Abo-Elkhier A.A-E., , Abdel-Wahab K.S.E., , Ali M.A., , El-Sayed M.A-H., , Saleh. N.A-K., and Atef A.A. , 2005. Assessment of Hepatitis E Viral Infection and Its Effect on Egyptian Pregnant Mothers. International Journal of Virology, 1: 65-65.

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