Abstract: Background and Objective: Potato (Solanum tuberosum L.) is one of an important food and cash generating crop in the northwestern parts of Ethiopia and particularly of Awi zone where it is grown three times per annum. However, its productivity is very low since, separate use of fertilizer, absence of balanced fertilizer and no recommendation on integrated use of organic and inorganic fertilizers for the area. The aim of study was to investigate the best combination of blended NPSZnB fertilizer and cattle manure for the better production of potato. Materials and Methods: For this purpose, an experiment was conducted at Banja district, Awi Zone during rainy season of 2017. Four different levels of blended NPSZnB fertilizer (0, 65.7, 133 and 199 t ha–1) and four levels of cattle manure (0, 10, 20 and 30 t ha–1) were factorially combined and tested for effect on the yield and yield component of potato in a randomized complete block design (RCBD). Results: Results of analysis of variance revealed that significant effect of treatments on marketable and total tuber yield and total dry biomass yield. The combined application of 199 kg ha–1 blended NPSZnB fertilizer and 30 t ha–1 cattle manure significantly affected the indicated parameters. However, marketable tuber number and total tuber number were significantly affected by blended NPSZnB fertilizer (199 kg ha–1) alone, Harvest index (%) and total dry biomass were significantly affected by cattle manure (30 t ha–1) alone, while average tuber weight was significantly affected by blended NPSZnB fertilizer (199 kg ha–1) alone and cattle (30 t ha–1) manure alone but not interaction. Conclusion: Application of 199 kg ha–1 blended NPSZnB fertilizer level with 30 t ha–1 cattle manure should be used for better yield and yield component performance of dagim potato variety at study area.