Abstract: Background and Objective: The decline in soil fertility in the smallholder farmers’ fields has resulted in low kernel yields in Zambia. Therefore, a field study was conducted to improve kernel yields by assessing the effect of B, Ca, N, P and K fertilizer application on groundnuts. Materials and Methods: A field trial was conducted at Golden Valley Agricultural Trust (GART) in Chisamba District of Zambia for two consecutive growing seasons of 2014/15 and 2015/16. The field experiment was laid out in a randomised complete block design with three replications. Randomisation of the following treatments was done per block: (i) No fertilizer, (ii) N20, (iii) N20P30, (iv) N20P30Ca100, (v) N20P30Ca100K40 and (vi) N20P30Ca100K40B1. The numbers in subscript indicate rates of the nutrients in kg ha–1. Analysis of variance was used to analyse the data. Results: Compared to the control (0 kg ha–1), groundnuts responded to the application of N20P30Ca100K40B1 kg ha–1 to result in an increase of Ca uptake by 21%, N uptake by 55.5% and P uptake by 51%. . The response of groundnuts to N20P30Ca100 kg ha–1 resulted in an increase in kernels by 65.5% and haulm yield by 83.4%. Conclusion: The uptake of nutrient-elements by MGV 5 depended on application of all the nutrients at the rate of Ca100N20P30K40B1 kg ha–1. The appropriate rate of Ca, N and P fertilizers vital in attaining optimum kernel and haulm yields on a low fertility status acid soils in Zambia and areas with similar agro-ecological conditions is Ca100N20P30 kg ha–1.