Abstract: The study was conducted to investigate the effect of liming, Bradyrhizobium inoculation and nitrogen fertilization on nodulation and growth response of Clark 63-K soybean variety at Melko, Jimma in 2012 growing season. The crop was evaluated for nodule number, nodule volume, nodule dry weight, pod bearing branch number, shoot dry weight and plant height. The combined effect of liming and Bradyrhizobium inoculation significantly (p<0.05) increased nodule number, nodule volume and nodule weight dry per plant compared to un-limed and non-inoculated treatments. On the other hand, nitrogen fertilization did not improve nodulation parameters of the crop nor its interaction with lime and Bradyrhizobium was significant. Application of lime and nitrogen gave more branch number, shoot dry weight and taller soybeans than non-limed and unfertilized treatment when the crop was grown without inoculation. However, regardless of nitrogen fertilization, only lime significantly (p<0.05) improved those investigated growth parameters when the soybean was grown symbiotically with Bradyrhizobium. In acid soils, co-treatment of Bradyrhizobium japonicum and lime could complement for chemical fertilizer N in soybean production.